Implementing EFF-TOX and Monotone Utility Based Phase 12 Trials

Contains functions for simulating phase 12 trial designs described by Chapple and Thall (2019) including simulation and the EFF-TOX trial and simulation and implementation of the U12 trial. Functions for implementing the EFF-TOX trial are found in the package 'Phase123'.


Reference manual

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1.0 by Andrew G Chapple, 2 years ago

Browse source code at

Authors: Andrew G Chapple

Documentation:   PDF Manual  

GPL-2 license

Imports Rcpp, bindata, mvtnorm, Phase123

Linking to Rcpp, RcppArmadillo

See at CRAN