Design and Analysis of Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control

Design and analyze three-arm non-inferiority or superiority trials which follow a gold-standard design, i.e. trials with an experimental treatment, an active, and a placebo control.

To install the released version from CRAN:


To install the development version from github:

# install.packages("devtools")


title: "News for ThreeArmedTrials" author: "Tobias Mütze" date: "May 11th 2016"

ThreeArmedTrials 1.0-0

  • Binary, censored exponential, nonparametric, normal, Poisson models implemented
  • Functions taNegbin.test(), taNegBin.OptAllocation(), and power.taNegbin.test() are marked as deprecated
  • Negative binomial model is part of new functions test_RET(), power_RET(), and opt_alloc_RET()
  • Data sets GElesions, remission, seizures, and T2lesion added to package
  • Vignette with examples for binary, Poisson, and nonparametric model made available

ThreeArmedTrials 0.1-0

  • Package includes all functions for plannung and analyzing trials with negative binomial endpoints
  • First version published on CRAN

Reference manual

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1.0-0 by Tobias Muetze, 9 months ago

Report a bug at

Browse source code at

Authors: Tobias Muetze [aut, cre], Tim Friede [ctb]

Documentation:   PDF Manual  

Task views: Design of Experiments (DoE) & Analysis of Experimental Data

GPL (>= 2) license

Imports stats, MASS, numDeriv

Suggests testthat, knitr, rmarkdown

See at CRAN