Design and Analysis Tools for Target Trial Emulation

Design and analysis tools for target trial emulation using longitudinal observational data. Functions are provided for checking person-period data, expanding longitudinal data into sequentially nested trials, estimating inverse probability weights for intention-to-treat and per-protocol analyses, and assessing weight distributions and covariate balance. Additional functions fit weighted pooled discrete-time outcome models, obtain standardized risks and treatment contrasts, and estimate weighted Kaplan-Meier and Aalen-Johansen curves. Two worked examples based on fully synthetic data illustrate an active-comparator new-user study comparing sodium-glucose cotransporter 2 inhibitors with dipeptidyl peptidase-4 inhibitors and an analysis of sequentially nested trials comparing angiotensin receptor blocker and calcium channel blocker strategies.


Reference manual

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install.packages("TTE")

1.1.2 by Hisashi Noma, a month ago


https://github.com/nomahi/TTE/


Browse source code at https://github.com/cran/TTE


Authors: Hisashi Noma [aut, cre] (ORCID:


Documentation:   PDF Manual  


GPL-3 license


Imports graphics, nnet, sandwich, stats, utils

Suggests testthat


See at CRAN