Target Equivalence Range Design

The TEQR package contains software to calculate the operating characteristics for the TEQR and the ACT designs.The TEQR (toxicity equivalence range) design is a toxicity based cumulative cohort design with added safety rules. The ACT (Activity constrained for toxicity) design is also a cumulative cohort design with additional safety rules. The unique feature of this design is that dose is escalated based on lack of activity rather than on lack of toxicity and is de-escalated only if an unacceptable level of toxicity is experienced.


Reference manual

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6.0-0 by M. Suzette Blanchard, 4 years ago

Browse source code at

Authors: M. Suzette Blanchard

Documentation:   PDF Manual  

Task views: Clinical Trial Design, Monitoring, and Analysis, Design of Experiments (DoE) & Analysis of Experimental Data

GPL-2 license

See at CRAN