Modeling and Assessing Similarity of Drug Dissolutions Profiles

Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) for details.


Reference manual

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0.1.0 by Kathrin Moellenhoff, a year ago

Browse source code at

Authors: Kathrin Moellenhoff

Documentation:   PDF Manual  

GPL (>= 2) license

Depends on dplyr, alabama, mvtnorm, graphics

See at CRAN