Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, < https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.


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install.packages("Phase12Compare")

1.3 by Andrew G Chapple, a month ago


Browse source code at https://github.com/cran/Phase12Compare


Authors: Andrew G Chapple


Documentation:   PDF Manual  


GPL-2 license


Imports Rcpp, mvtnorm

Linking to Rcpp, RcppArmadillo


See at CRAN