Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.


Reference manual

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1.5 by Andrew G Chapple, a year ago

Browse source code at

Authors: Andrew G Chapple

Documentation:   PDF Manual  

GPL-2 license

Imports Rcpp, mvtnorm

Linking to Rcpp, RcppArmadillo

See at CRAN