Probabilistic Two Sample Mendelian Randomization

Efficient statistical inference of two-sample MR (Mendelian Randomization) analysis. It can account for the correlated instruments and the horizontal pleiotropy, and can provide the accurate estimates of both causal effect and horizontal pleiotropy effect as well as the two corresponding p-values. There are two main functions in the 'PPMR' package. One is PMR_individual() for individual level data, the other is PMR_summary() for summary data.


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install.packages("PPMR")

1.0 by Michael Kleinsasser, 15 days ago


Report a bug at https://github.com/umich-biostatistics/PPMR/issues


Browse source code at https://github.com/cran/PPMR


Authors: Zhongshang Yuan [aut] , Xiang Zhou [aut] , Michael Kleinsasser [cre]


Documentation:   PDF Manual  


GPL-3 license


Imports Rcpp

Linking to Rcpp, RcppArmadillo


See at CRAN