A Causal Mediation Method with Methylated Region (MR) as the Mediator

A causal mediation approach under the counterfactual framework to test the significance of total, direct and indirect effects. In this approach, a group of methylated sites from a predefined region are utilized as the mediator, and the functional transformation is used to reduce the possible high dimension in the region-based methylated sites and account for their location information.


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Reference manual

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install.packages("MRmediation")

1.0.0 by Qi Yan, 5 months ago


Browse source code at https://github.com/cran/MRmediation


Authors: Qi Yan


Documentation:   PDF Manual  


GPL (>= 2) license


Imports MASS, stats

Depends on fda


See at CRAN