Design and Analysis of Dose-Finding Studies

Implements a methodology for the design and analysis of dose-response studies that combines aspects of multiple comparison procedures and modeling approaches (Bretz, Pinheiro and Branson, 2005, Biometrics 61, 738-748, ). The package provides tools for the analysis of dose finding trials as well as a variety of tools necessary to plan a trial to be conducted with the MCP-Mod methodology. Please note: The 'MCPMod' package will not be further developed, all future development of the MCP-Mod methodology will be done in the 'DoseFinding' R-package.


USER-VISIBLE CHANGES (for detailed changes see ChangeLog in the source package)

Version 1.0 (February 2009)

  • The package now includes a vignette describing methodology and package. The package R source code is identical to versions 0.2-1 and 0.2-2.

Version 0.2 (December 2008)

  • There will be an article in Journal of Statistical Software describing the package. This paper refers to version 0.2-1 of the package.

Version 0.1 (April 2008)

  • First release.

Reference manual

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1.0-10 by Bjoern Bornkamp, 8 months ago

Browse source code at

Authors: Bjoern Bornkamp, Jose Pinheiro and Frank Bretz

Documentation:   PDF Manual  

Task views: Clinical Trial Design, Monitoring, and Analysis

GPL-3 license

Depends on mvtnorm, lattice

See at CRAN