MArginal ePIstasis Test for Regions

A genetic analysis tool and variance component model for identifying marginal epistasis between pathways and the rest of the genome. 'MAPITR' uses as input a matrix of genotypes, a vector of phenotypes, and a list of pathways. 'MAPITR' then iteratively tests each pathway for epistasis between any variants within the pathway versus any variants remaining in the rest of the genome. 'MAPITR' returns results in the form of p-values for every pathway indicating whether the null model of there being no epistatic interactions between a pathway and the rest of the genome can be rejected.


Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


1.1.2 by Michael Turchin, 4 months ago

Report a bug at

Browse source code at

Authors: Michael Turchin [aut, cre] , Gregory Darnell [aut, ctb] , Lorin Crawford [aut, ctb] , Sohini Ramachandran [aut] , Peter Carbonetto [ctb]

Documentation:   PDF Manual  

MIT + file LICENSE license

Imports stats, doParallel, Rcpp, CompQuadForm

Suggests testthat, knitr, rmarkdown

Linking to Rcpp, RcppArmadillo

See at CRAN