Plotting N-T Plane for Decision on Performing an Interim Analysis

In randomized-controlled trials, interim analyses are often planned for possible early trial termination to claim superiority or futility of a new therapy. Blinded data also have information about the potential treatment difference between the groups. We developed a blinded data monitoring tool that enables investigators to predict whether they observe such an unblinded interim analysis results that supports early termination of the trial. Investigators may skip some of the planned interim analyses if an early termination is unlikely. This tool will provide reference information about N: Sample size at interim analysis, and T: Total number of responders at interim analysis for decision on performing an interim analysis.


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1.0 by Kyongsun Pak, 4 years ago

Browse source code at

Authors: Kyongsun Pak

Documentation:   PDF Manual  

GPL (>= 2) license

Imports graphics, stats

Suggests testthat, evaluate, knitr

See at CRAN