Sample Size Calculation in Hierarchical 2x2 Factorial Trials

Implements the sample size methods for hierarchical 2x2 factorial trials under two choices of effect estimands and a series of hypothesis tests proposed in "Sample size calculation in hierarchical 2x2 factorial trials with unequal cluster sizes" (under review), and provides the table and plot generators for the sample size estimations.


Reference manual

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2.0.0 by Zizhong Tian, 6 months ago

Browse source code at

Authors: Zizhong Tian [aut, cre] , Denise Esserman [aut] , Guangyu Tong [aut] , Fan Li [aut]

Documentation:   PDF Manual  

LGPL (>= 2.1) license

Imports mvtnorm

Suggests knitr, rmarkdown

See at CRAN