Genotype-Specific Survival Estimation

We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.


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0.1 by Baosheng Liang, 6 years ago

Browse source code at

Authors: Baosheng Liang , Yuanjia Wang and Donglin Zeng

Documentation:   PDF Manual  

Task views: Survival Analysis

GPL (>= 2) license

Imports Iso, splines, stats, zoo

Suggests MASS

See at CRAN