Joint Test of Gene and GxE Interactions via Varying Coefficients

A novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) .


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1.0.0 by Sydney Manning, a year ago

Browse source code at

Authors: Zhengyang Zhou [aut] Sydney Manning [aut, cre] Chao Xing [aut] Hung-Chih Ku [aut]

Documentation:   PDF Manual  

GPL-3 license

Imports nlme, RLRsim, stats

Suggests rmarkdown, knitr

See at CRAN