Escalation with Overdose Control using 2 Drug Combinations

Implements escalation with overdose control (EWOC) trial designs using two drug combinations described by Tighiouart, Li and Rogatko (2017) . It calculates the recommended dose for next cohorts and perform simulations to obtain operating characteristics.


Reference manual

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1.0 by Quanlin Li, 2 years ago

Browse source code at

Authors: Quanlin Li and Mourad Tighiouart

Documentation:   PDF Manual  

GPL (>= 2) license

Imports MASS

Depends on rjags

See at CRAN