Imputing Dropout Events in Single-Cell RNA-Sequencing Data

R codes for imputing dropout events. Many statistical methods in cell type identification, visualization and lineage reconstruction do not account for dropout events ('PCAreduce', 'SC3', 'PCA', 't-SNE', 'Monocle', 'TSCAN', etc). 'DrImpute' can improve the performance of such software by imputing dropout events.

Il-Youp Kwak ([email protected]), with contributions from Wuming Gong.

R/DrImpute is an R package for imputing dropout events in single-cell RNA-sequencing data. It improve many statistical tools used for scRNA-seq analysis that do not account for dropout events.


From CRAN :


Or, with devtools:



The R/DrImpute package is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License, version 3, as published by the Free Software Foundation.

This program is distributed in the hope that it will be useful, but without any warranty; without even the implied warranty of merchantability or fitness for a particular purpose. See the GNU General Public License for more details.

A copy of the GNU General Public License, version 3, is available at


Reference manual

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1.0 by Il-Youp Kwak, 5 years ago

Browse source code at

Authors: Il-Youp Kwak with contributions from Wuming Gong

Documentation:   PDF Manual  

Task views: Missing Data

GPL-3 license

Imports Rcpp

Suggests knitr, rmarkdown, devtools, roxygen2, irlba

Linking to Rcpp, RcppArmadillo

See at CRAN