Colony Formation Assay: Taking into Account Cellular Cooperation

Cellular cooperation compromises the plating efficiency-based analysis of clonogenic survival data. This tool provides functions that enable a robust analysis of colony formation assay (CFA) data in presence or absence of cellular cooperation. The implemented method has been described in Brix et al. (2020). (Brix, N., Samaga, D., Hennel, R. et al. "The clonogenic assay: robustness of plating efficiency-based analysis is strongly compromised by cellular cooperation." Radiat Oncol 15, 248 (2020). ) Power regression for parameter estimation, calculation of survival fractions, uncertainty analysis and plotting functions are provided.


Reference manual

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1.0.0 by Daniel Samaga, 5 months ago

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Authors: Daniel Samaga [cre, aut] , Nikko Brix [aut] , Kirsten Lauber [aut] , Horst Zitzelsberger [aut]

Documentation:   PDF Manual  

GPL-3 license

Imports Hmisc

Suggests knitr, rmarkdown, testthat

See at CRAN