Bayesian Evaluation of Variant Involvement in Mendelian Disease

A fast integrative genetic association test for rare diseases based on a model for disease status given allele counts at rare variant sites. Probability of association, mode of inheritance and probability of pathogenicity for individual variants are all inferred in a Bayesian framework - 'A Fast Association Test for Identifying Pathogenic Variants Involved in Rare Diseases', Greene et al 2017 .


News

BeviMed 5.1

  • New function, subset_variants, which retains only variants with data bearing upon pathogenicity.
  • Return posterior mean of omega even when not explicitly sampled in summary.BeviMed_m.

BeviMed 5.0

  • bevimed_polytomous function added which enables application of BeviMed across multiple association models.
  • BeviMed objects now more general, representing results of inference with respect to the baseline model gamma = 0 and an arbitrary number of alternative association models - typically, one for each mode of inheritance. The $moi slot has been replaced with $models.
  • prob_pathogenic now returns a list when broken down by mode of inheritance/model.

BeviMed 4.3

  • Make BeviMed work smoothly when number of individuals or number of variants is 0.
  • Retain names of variants from columns of original allele count matrix.
  • Improvements to guide, with more detail on model selection.

BeviMed 4.2

  • Fixed bug in calculation of expected number of explaining variants by only including those with pathogenic configurations.

BeviMed 4.0

  • Previous bevimed function now replaced by bevimed_m, with the _m indicating that it conditions on mode of inheritance.
  • bevimed now integrates over indicator of association (gamma) and mode of inheritance (m), allowing user to specify priors on probability of association and probability of dominance.
  • The BeviMed class object has been replaced by BeviMed_m, and a new BeviMed class has been introduced for inference with respect to all models: gamma 0 and gamma 1 under each mode of inheritance.
  • A new vignette with more detail called BeviMed Guide which relates the package to the paper.
  • Names used for summary statistics in summary objects have changed, see function help pages for details on current names.
  • printing a BeviMed object now shows conditional probabilities of pathogenicity for each mode of inheritance, and expected explained cases and expected explaining variants shown too.
  • Bug fixed in adaptive tuning for omega and phi proposals.

BeviMed 3.0

  • Re-naming of parameters in bevimed function to match the names of variables in the paper (under submission).
  • The allele count matrix G should now be supplied as a matrix with rows corresponding to individuals, not variants.
  • expected_explained and explaining_variants functions have been added, respectively computing the expected number of cases with their disease explained by the given variants, and expected number of pathogenic variants present amongst cases.

Reference manual

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install.packages("BeviMed")

5.3 by Daniel Greene, a year ago


Browse source code at https://github.com/cran/BeviMed


Authors: Daniel Greene , Sylvia Richardson and Ernest Turro


Documentation:   PDF Manual  


GPL (>= 2) license


Imports Rcpp

Suggests knitr

Linking to Rcpp


See at CRAN