Bayesian Single-Arm Design with Survival Endpoints

The proposed event-driven approach for Bayesian two-stage single-arm phase II trial design is a novel clinical trial design and can be regarded as an extension of the Simon’s two-stage design with the time-to-event endpoint. This design is motivated by cancer clinical trials with immunotherapy and molecularly targeted therapy, in which time-to-event endpoint is often a desired endpoint.


Reference manual

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0.1.1 by Chia-Wei Hsu, 9 days ago

Browse source code at

Authors: Chia-Wei Hsu [aut, cre] , Haitao Pan [aut] , Jianrong Wu [aut]

Documentation:   PDF Manual  

GPL-2 license

See at CRAN