Adaptive Subgroup Selection in Group Sequential Trials

Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, ). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.

ASSISTant

ASSISTant is a package to assist in performing Adaptive Subgroup Selection In Sequential Trials.

ASSISTant provides a three-stage adaptive group sequential clinical trial design with provision for selecting a subgroup where the treatment may be effective. The package provides facilities for design, exploration and analysis of such trials using either continuous or discrete outcomes. A complete implementation of the initial design for the DEFUSE-3 trial is also provided as a vignette.