Clinical trial design for subgroup selection in three-stage group sequential trial. Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.
ASSISTant is a package to assist in performing Adaptive
Subgroup Selection In Sequential Trials.
Install this package (after taking care of dependencies shown) the usual way in R once it gets on CRAN or via:
ASSISTant provides a three-stage adaptive group sequential clinical
trial design with provision for selecting a subgroup where the
treatment may be effective. The package provides facilities for
design, exploration and analysis of such trials. A complete
implementation of the initial design for the DEFUSE-3 trial is
also provided as a vignette.