Adaptive Subgroup Selection in Group Sequential Trials

Clinical trial design for subgroup selection in three-stage group sequential trial. Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.

Travis-CI Build Status CRAN_Status_Badge

ASSISTant is a package to assist in performing Adaptive Subgroup Selection In Sequential Trials.

ASSISTant provides a three-stage adaptive group sequential clinical trial design with provision for selecting a subgroup where the treatment may be effective. The package provides facilities for design, exploration and analysis of such trials using either continuous or discrete outcomes. A complete implementation of the initial design for the DEFUSE-3 trial is also provided as a vignette.


ASSISTant 1.4-2

  • Added Rankin Score vignette
  • Generated pkgdown docs

ASSISTant 1.4-1

  • Fixed typo in setBoundaries()
  • Updated discrete Rankin score parts

ASSISTant 1.4

  • Wilcoxon fix for Discrete Data
  • Added discrete data simulation capability

ASSISTant 1.3

  • Fixed up boundary calculation bugs
  • Added computation of stage statistics
  • Added confidence intervals per Ka Wai Tsang

ASSISTant 1.2-2

  • First CRAN submission

ASSISTant 1.2

  • Added power calculations
  • Added more vignettes
  • Fixed typos

ASSISTant 1.0

  • Initial package for testing

Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


1.4.2 by Balasubramanian Narasimhan, 2 years ago

Report a bug at

Browse source code at

Authors: Tze Leung Lai [ctb] , Philip Lavori [aut] , Olivia Liao [aut] , Balasubramanian Narasimhan [aut, cre] , Ka Wai Tsang [aut]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports R6, mvtnorm, knitr, magrittr, dplyr

Suggests rmarkdown

See at CRAN