Adaptive Subgroup Selection in Group Sequential Trials

Clinical trial design for subgroup selection in three-stage group sequential trial. Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.


ASSISTant is a package to assist in performing Adaptive Subgroup Selection In Sequential Trials.

Install this package (after taking care of dependencies shown) the usual way in R once it gets on CRAN or via:

require("mvtnorm")
require("R6")
library(devtools)
install_github("bnaras/ASSISTant")

ASSISTant provides a three-stage adaptive group sequential clinical trial design with provision for selecting a subgroup where the treatment may be effective. The package provides facilities for design, exploration and analysis of such trials. A complete implementation of the initial design for the DEFUSE-3 trial is also provided as a vignette.

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Reference manual

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install.packages("ASSISTant")

1.2-3 by Balasubramanian Narasimhan, a year ago


https://github.com/bnaras/ASSISTant


Report a bug at https://github.com/bnaras/ASSISTant/issues


Browse source code at https://github.com/cran/ASSISTant


Authors: Tze Leung Lai [ctb], Philip Lavori [aut], Olivia Liao [aut], Balasubramanian Narasimhan [aut, cre], Ka Wai Tsang [aut]


Documentation:   PDF Manual  


GPL (>= 2) license


Imports R6, mvtnorm

Suggests knitr, rmarkdown


See at CRAN